DPPC vesicle Coarse-grained lipid head groups from MDAnalysis test data, with their tails.
Service 06
Immunoinformatics and in silico vaccine design
Multi-epitope vaccine design from proteome to construct: epitope prediction, antigenicity, allergenicity and toxicity screening, construct design, receptor docking and molecular dynamics. About 5 days.
What we do
The work, step by step
- 01
Antigen selection
Choosing target proteins from the pathogen’s proteome.
- 02
Epitope prediction
B-cell and T-cell (MHC class I and II) epitopes, screened for antigenicity, allergenicity and toxicity.
- 03
Construct design
Epitopes joined with linkers and an adjuvant into a multi-epitope vaccine construct, with its physicochemical properties.
- 04
Structure and validation
Three-dimensional model of the construct, refined and validated.
- 05
Receptor docking and dynamics
Docking to immune receptors and molecular dynamics to test the stability of the complex.
You receive
- Epitope tables
- The vaccine construct sequence and model
- Docking and dynamics results
- A written methods and results section
Typical turnaround
5 days from proteome to construct
Counted from the day we receive your files. Larger studies get their own timeline with the quote. All turnaround times
Tools
Standard epitope-prediction and screening servers, structure prediction and refinement, docking, and GROMACS for molecular dynamics. The founder has published many multi-epitope vaccine designs (see Research).
Who works on it
Muhammad Nouman Majeed, with the BioInfoX research team. We take full responsibility for every analysis we perform.
Start
Send us your system and your question.
Structures, sequences or data, your research question and your deadline. We reply with the scope, the timeline and a quote.